THis project was an extension of a previously funded CRDF grant. Funding for both overlapped during this year with just minor funds available in the base 330 project. Therefor results presented in the March 2014 report are the same for both projects and are repeated in the quarterly reports: As a result of our compositional structural and enzymatic analysis of psyllid sheath structure and biosynthesis, we identified a class of natural products (Generally Regarded as Safe ‘GRAS’ compounds) that could inhibit sheath biosynthesis. These compounds were selected based on the probability that their structure would be competitive with the substrates used in the sheath polymerizing process. Twelve such compounds were selected and tested for sheath inhibition. Of the twelve, the presence of 10 in the media in which these insects fed resulted in aberrant sheath formation. These are now being tested in dose studies and in combination. The doses and combinations showing the best response will be used in greenhouse application studies. The discovery of GRAS compounds that have affect on sheath formation offers the possibility of a rapid commercialization process if they are shown to be effective in whole plant application trials. Some of the tested compounds are available at relatively low costs that would be compatible with commercialization if efficacy as a topically applied compound can be verified.