Which commercial adjuvants achieve systemic delivery of antimicrobials?

Which commercial adjuvants achieve systemic delivery of antimicrobials?

Report Date: 12/16/2020
Project: 19-023   Year: 2021
Category: CLas Bacteria
Author: Christopher Vincent
Sponsor: Citrus Research and Development Foundation

We have no new results to report except that COVID-related delays in materials procurement have been overcome and quantification of oxy-tetracylcine and streptomycin for the final two experiments are now in process, and will be completed in the coming weeks. We have now completed the field portions of the studies proposed, as well as of a follow-up study to confirm the results of both of the first studies.  The field study of delivery of oxytetracycline (OTC) has now been published in the journal Antibiotics (Killiny et al., 2020). Overall the results conclude that:1. OTC moved systemically, though a significant portion was trapped in the leafs into which it originally came in contact.2. Most foliarly applied OTC was lost.  This was determined by comparison with injection. Less tha3. No adjuvant delivered significant quantities of OTC.  4. Only injection reduced polulation of HLB-causing Candidatus Liberibacter asiaticus (CLas). COVID-19-related delays in supplies have delayed quantification of streptomycin, though we now have assurances that the supplies will be delivered before the start of 2021.  In the meantime, OTC quantification from the follow-up study, and CLas quantification are progressing for the follow-up study and the streptomycin-specific study. We anticipate publication of results within the 4 remaining months of the project.  PublicationKilliny, N., Hijaz, F., Gonzalez-Blanco, P., Jones, S. E., Pierre, M. O., & Vincent, C. I. (2020). Effect of Adjuvants on Oxytetracycline Uptake upon Foliar Application in Citrus. Antibiotics, 9(10), 677.  


Your browser does not support pdfs, click here to download the file.